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Narcolepsy vs Depression are two separate medical disorders with unique symptoms. Excessive daytime sleepiness, abrupt muscle weakness (cataplexy), and irregular sleep patterns are symptoms of the neurological condition narcolepsy. In contrast, depression is a type of mood illness marked by a lack of interest in or enjoyment from daily activities, as well as persistent emotions of melancholy and hopelessness. Although they can both affect day-to-day functioning, the diagnosis and treatment of both illnesses must be approached differently.