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An off-label application of modafinil is to alleviate myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) symptoms. Medical professionals treating chronic fatigue syndrome (CFS) may recommend modafinil to their patients in an effort to increase alertness and decrease sleepiness, even though the drug has not been officially authorized for this use. Modafinil has shown promise in treating chronic fatigue syndrome (CFS), however, its efficacy may vary from person to person. Furthermore, further study is required to completely comprehend the advantages and possible hazards of its usage in CFS, and its use is still somewhat contentious. It is crucial to see a healthcare provider who can provide individualized advice and suggestions based on your unique symptoms and medical history if you are contemplating the use of modafinil or any other drug for chronic fatigue syndrome.