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CA9/CAIX (carbonic anhydrase 9) is a zinc metalloenzyme catalyzing the reversible hydration of carbon dioxide. Physiologically, CA9 participates in a variety of biological processes including respiration, calcification, acid-based balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, gastric acid, etc. as a transmembrane protein, and involves in cell proliferation and transformation. Learn more: anti-CA9 CAR-T in vivo assay