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The most serious side effect of Metformin Hcl 500 Mg, a commonly prescribed medication for type 2 diabetes, is a rare but potentially life-threatening condition called lactic acidosis. Lactic acidosis occurs when there is a buildup of lactic acid in the bloodstream, leading to symptoms such as rapid breathing, muscle weakness, confusion, and in severe cases, coma. It is crucial to note that lactic acidosis is rare, but it is more likely to occur in individuals with kidney problems, liver issues, or those who misuse alcohol. Metformin Hydrochloride 500 Mg Regular monitoring and adherence to prescribed dosages, especially in those with underlying health conditions, help minimize the risk of this serious side effect.